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Further alterations in intracellular redox balance driven by lower GSH availability induce cell death and enhance T2 signature protein expression We previously demonstrated that 15LO1-PEBP1 complex activation consistently upregulates the expression of T2-signature gene/protein expression, including MUC5AC, periostin (POSTN), and CCL26 (6, 10, 14)

In naturally aged mice and in doxorubicin-treated mice, FOXO4-DRI treatment significantly improved physical fitness, restored fur density, improved renal function, and improved liver function effects attributed to the selective elimination of accumulated senescent cells

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Caeque T, Baron L, Mller S, Carmona A, Colombeau L, Versini A, et al